Your compliance is crucial to the success of the goals of the RIC Biosafety Program. Those working with recombinant DNA (rDNA) and/or biological materials are required to submit a Biological Project Registration Form to the Institutional Biosafety Committee. In some cases the form must go through review before laboratory work may begin. The following activities are exempt from full review, but still require the submission of a Biological Project Registration Form.
rDNA that does not present a significant risk to health or the environment
rDNA that is not in organisms or viruses
rDNA consisting entirely of DNA segments from a single non-chromosomal or viral DNA source
rDNA consisting entirely of DNA from a prokaryotic host including its indigenous plasmids or viruses when propagated only in that host or when transferred to another host by well established physiological means.
rDNA consisting entirely of DNA from a eukaryotic host including its chloroplasts, mitochondria, or plasmids when propagated only in that host.
rDNA consisting entirely of DNA segments from different species that exchange DNA by known physiological processes.
The rDNA activities listed above are exempt from full review before labwork is initiated; however, a Biological Project Registration Form must be filed with the IBC.
Activities involving Biological Materials, work with live organisms, and animals:
Biosafety Level 1 (BSL1) materials are not known to cause disease in healthy adults are exempt from full review. A Biological Project Registration Form must be filed with the IBC.
Fluids, tissues, cells and other biological material of human or non-human primate origin are classified as BSL2. Projects involving BSL2 materials are
not exempt from full IBC review and are not authorized until the protocols are reviewed and approved by the IBC.
Use of the following
Select Agents in research must go through IBC approval before obtaining materials.
Abrin, Conotoxins, Diacetoxyscirpenol (DAS), Ricin, Saxitoxin, Tetrodotoxin, Shiga-like ribosome inactivating proteins, Botulinum neurotoxins, Clostridium perfringens epsilon toxin, Shigatoxin, Staphylococcal enterotoxins, T-2 toxin